Cloned (Comment) | Organism |
---|---|
SENP3 quantitative real-time PCR expression analysis | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | SUMO-2/3-conjugated targets are more successfully deconjugated by SENP3 than SUMO-1-containing species | ? | - |
? | |
additional information | Mus musculus ICR | SUMO-2/3-conjugated targets are more successfully deconjugated by SENP3 than SUMO-1-containing species | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Mus musculus ICR | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Mus musculus | - |
brain | spatial and temporal expression patterns of SENP3, overview | Mus musculus | - |
cerebral cortex | dynamic changes in SENP3 expression in the cerebral cortex and in its cellular localization in traumatic brain injury compared to normal, overview | Mus musculus | - |
additional information | immunohistochemical and expression anaysis of the enzyme in brain tissues, overview | Mus musculus | - |
neuron | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | SUMO-2/3-conjugated targets are more successfully deconjugated by SENP3 than SUMO-1-containing species | Mus musculus | ? | - |
? | |
additional information | enzyme SENP3 deconjugates SUMO2/3 from protein substrates | Mus musculus | ? | - |
? | |
additional information | SUMO-2/3-conjugated targets are more successfully deconjugated by SENP3 than SUMO-1-containing species | Mus musculus ICR | ? | - |
? | |
additional information | enzyme SENP3 deconjugates SUMO2/3 from protein substrates | Mus musculus ICR | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SENP3 | - |
Mus musculus |
SUMO-specific proteases 3 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | traumatic brain injury upregulates the enzyme expression in the brain, especially in the neurons and astrocytes | up |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme is a member of the small ubiquitin-like modifier-specific protease family | Mus musculus |
physiological function | the enzyme SENP3 is critical for maintaining the level of SUMOylated and un-SUMOylated substrates required for normal physiology because of its isopeptidase activity, whereby it cleaves the isopeptide bond between SUMO and substrate proteins, as a result, SENP3 may weaken the neuroprotective effect of SUMO-2/3 | Mus musculus |